19-Nights The Wonders of Peru, The Andean Explorer, and the Galapagos onboard Yacht Isabela II from $27,349

Located at the ‘mouth’ of the head of the sea horse, which forms the northern part of the Galapagos islands, is Punta Vicente Roca, Here the remnants of an ancient volcano form two turquoise coves with a bay well protected from the ocean swells.

The spot is a popular anchorage from which to take panga rides along the cliff that are the remains of the volcano or explore a partially sunken cave at the water’s edge. Masked and blue-footed boobies sit perched along the point and the sheer cliffs, while flightless cormorants inhabit the shoreline.

The upwelling of coldwater currents in this part of the Galapagos, give rise to an abundance of marine life which, in combination with the protection of the coves, make Punta Vicente Roca one of the archipelago’s sough after dive spots.

One cove is only accessible from the sea by way of an underwater passage. The passage opens to calm waters of the hidden cove where sea lions like to laze on the beach having traveled along the underwater route. The entire area of Punta Vicente Roca lies on the flank of 2,600 foot Volcano Ecuador.This is the Galapagos island’s sixth largest volcano. Half of Volcano Ecuador slid into the ocean leaving a spectacular cutaway view of the volcanic caldera.

Also known as San Salvador or James, Santiago is the fifth-largest and one of the most visited of the Galapagos Islands. It is uninhabited, and there was a failed attempt at colonizing it in the 1930s. There are three visitor sites, and the two on the western coast of the island are Puerto Egas and Playa Espumilla.

Puerto Egas, on James Bay, offers a black-sand landing beach with impressive wind-carved, tuff-stone layers. The relatively flat, black-lava shoreline is broken up by pools, caves and promenades, where hundreds of marine iguanas sun themselves, seek mates and slither into the sea. Their black skin camouflages them among the lava rocks.

Playa Espumilla is a nesting area for sea turtles and, when the lagoon is filled, a place to see white-cheeked pintail ducks and flamingos. The estimated flamingo population on the Galapagos is around 500-1,000. These animals are an endemic subspecies of the flamingos commonly found in the Caribbean region.

Dozens of bright red-orange Sally Lightfoot crabs, among the only people-shy creatures on the islands, frolic in the tide pools and scurry on the rocks. The area also has a colony of fur seals, which are endemic to the islands but closely related to fur seals in Antarctica. The snorkeling is good along the rocks, where it's possible to see colorful fish, moray eels and sharks.

At the east end of the island is Sullivan's Bay (across from Bartolome Island). A volcano spewed a stream of lava there in 1897, and it still reaches to the sea. Visitors can follow a marked trail over the lava to see fascinating untouched volcanic formations such as pahoehoe lava. Only a few plants have taken hold there, including an unusually shaped cactus and some carpetweed.

Sombrero Chino (Chinese Hat) is a popular snorkeling spot 656 ft/200 m off the coast. These beautiful waters are a playground for sea lions, sharks, penguins and manta rays. A series of seven diving sites offer divers the chance to get up close to the best of Galapagos' marine life.

Sparkling in the sun, Arequipa is called the White City because of the sillar, a white volcanic stone that makes up its buildings, modern ones as well as Spanish colonial. Peru's second-largest city sits surrounded by towering mountains—including the 19,000-ft/5,800-m volcano El Misti.

The city itself is the home of the monastery of La Recoleta (with a museum and library) and several interesting churches, but its highlight is the Santa Catalina Convent. Built in the late 16th century (but closed to the public until 1970), it was a self-contained community, a place where nuns could worship and live without leaving the convent. Walk through the well-preserved structure, soak up the peaceful atmosphere and discover the tiny, secluded plazas and lovely courtyards within.

From Arequipa, take a guided tour of Colca Canyon, one of the deepest canyons in the world (10,500 ft/3,191 m deep). (Day trips are possible, but they require many hours in a bus and are not recommended; two- or three-day trips are preferable.) Several local agencies arrange two-day trips with pleasant overnights in rural hotels. A journey to the canyon offers a view of extensive pre-Incan and Incan agricultural terracing, some of which is still farmed today, as well as a chance to see Andean condors at Cruz del Condor, a lookout point.

Adventurous travelers can follow in the footsteps of the chasqui, the Incan foot messengers, and trek the canyon. The Cotahuasi Canyon is more remote than the Colca, but it is the deepest in the world, with stretches as low as 10,857 ft/3,300 m. It is located 125 mi/200 km northwest of Arequipa. Or visit the Reserva Nacional de Salinas y Aguada Blanca, a nature reserve with stunning lakes and salt flats, located high in the surrounding mountains. The area is about 465 mi/750 km southeast of Lima by air. By road, the distances are closer to 625 mi/1,000 km.