6-Nights Panama & Colombia Deluxe: Panama City & Cartagena from $3,032

Begin your 7-day adventure with an immersive boat tour along the Panama Canal. Embark on a jungle expedition across Gatun Lake, passing by giant cargo ships contrasting against the verdant backdrop of natural tropical jungles. Keep your eyes peeled for incredible local wildlife, including three-toed sloths sleeping in tree branches, ospreys hunting for peacocks from the sky, communities of snail kites, and keel-billed toucans before searching for white-faced capuchins, mantled howler monkeys, and more wildlife on the lake's rainforest-clad islands.

Discover the rest of Panama City on foot with a half-day walking tour across the city's UNESCO-listed historic centre, Casco Antiguo. Step back into the 1600s as you stroll through the district’s colonial houses, narrow avenues, and historic churches, including the famous golden altar at the Church of San Jose. Visit the Plaza de Francia, paying tribute to the French contributions to the Panama Canal, Los Bovedas, a monument once used against pirate attacks, and some of the city’s best museums, including the Museo del Canal and the Museo de la Mola.

Fly to Colombia’s Caribbean coast and immerse yourself in the vibrant port city of Cartagena. Discover Cartagena’s most iconic sites, including the imposing San Felipe de Barajas Fortress, one of the city’s most distinctive landmarks atop the San Lazaro Hill, part of the city’s defence against pirates. Venture even higher to La Popa Convent, where you'll find a pristine gold-plated altar dedicated to the Virgin de la Candelaria, patron saint of the city. Discover the vendors and locals along the sun-kissed streets before the sun sets, and your discovery of Cartagena’s nightlife begins. Begin with a cocktail at a sea-view lounge and a delicious dinner at a local restaurant before embracing the salsa rhythms at a lively bar, creating an unforgettable and authentic Cartagena atmosphere.